Eigene Publikationen zu dem Thema Sepsis mit externen Links zur Kurzform des jeweiligen Artikels

  1. Ito H, Murakami R, Sakuma S, Tsai CD, Gutsmann T, Brandenburg K, Pöschl JM, Arai F, Kaneko M, Tanaka M. Mechanical diagnosis of human erythrocytes by ultra-high speed manipulation unraveled critical time window for global cytoskeletal remodeling. Sci Rep. 2017 Feb 24;7:43134. doi: 10.1038/srep43134. https://www.ncbi.nlm.nih.gov/pubmed/28233788
  2. Yamada N, Martin LB, Zechendorf E, Purvis GS, Chiazza F, Varrone B, Collino M, Shepherd J, Heinbockel L, Gutsmann T, Correa W, Brandenburg K, Marx G, Schuerholz T, Brohi K, Thiemermann C. Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Ann Surg. 2017 Mar 10. doi: 10.1097/SLA.0000000000002186. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/28288070
  3. Pfalzgraff A, Heinbockel L, Su Q, Brandenburg K, Weindl G. Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses. Biochem Pharmacol. 2017 Sep 15;140:64-72. doi: 10.1016/j.bcp.2017.05.015. Epub 2017 May 21. https://www.ncbi.nlm.nih.gov/pubmed/28539262
  4. Sergio Bárcena-Varela1, Guillermo Martínez-de-Tejada1, Lukas Martin2, Tobias Schuerholz3, Ana Gloria Gil-Royo4, Satoshi Fukuoka5, Torsten Goldmann6,7, Daniel Droemann7,8, Wilmar Correa9, Thomas Gutsmann9, Klaus Brandenburg9* and Lena Heinbockel. Coupling killing to neutralization: Combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits. Experim. & Molec., Medicine (2017) Jun 16;49(6):e345. doi: 10.1038/emm.2017.75. https://www.ncbi.nlm.nih.gov/pubmed/28620220
  5. L. Martin, K. Horst, F. Chiazza, S. Oggero, M. Collino, K. Brandenburg, F. Hildebrand3, G. Marx, C. Thiemermann, T. Schuerholz. The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Sci. Rep 2016 6:37277 | DOI: 10.1038/srep37277 https://www.ncbi.nlm.nih.gov/pubmed/27853260
  6. Malgorzata-Miller G, Heinbockel LBrandenburg K, van der Meer JW, Netea MG, Joosten LA. Bartonella quintana lipopolysaccharide (LPS): structure and characteristics of a potent TLR4 antagonist for in-vitro and in-vivo applications. Sci Rep. 2016 Sep 27;6:34221. doi: 10.1038/srep34221. https://www.ncbi.nlm.nih.gov/pubmed/27670746
  7. Pfalzgraff A, Heinbockel L, Su Q, Gutsmann T, Brandenburg K, Weindl G. Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration. Sci Rep. 2016 Aug 11;6:31577. doi: 10.1038/srep31577. https://www.ncbi.nlm.nih.gov/pubmed/27509895
  8. Marcela Manrique-Moreno, Lena Heinbockel, Mario Suwalsky, Patrick Garidel, Klaus Brandenburg. Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserinebilayer membranes. Biochim. Biophys. Acta 1858 (2016) 2123–2131. https://www.ncbi.nlm.nih.gov/pubmed/27316371
  9. Brandenburg K, Heinbockel L, Correa W, Fukuoka S, Gutsmann T, Zähringer U, Koch M.H.J. Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5. J Struct Biol. 2016 Apr;194(1):68-77. doi: 10.1016/j.jsb.2016.01.014. Epub 2016 Jan 29. http://www.ncbi.nlm.nih.gov/pubmed/26828112
  10. Ulmer AJ, Kaconis Y, Heinbockel L, Correa W, Alexander C, Rietschel ET, Mach JP, Gorczynski RM, Heini A, Rössle M, Richter W, Gutsmann T, Brandenburg K. Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A. Innate Immunity 2016 Apr;22(3):168-80. doi: 10.1177/1753425916632304. Epub 2016 Feb 25 http://www.ncbi.nlm.nih.gov/pubmed/26921253
  11. Brandenburg K, Heinbockel L, Correa W, Lohner K. Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis. Biochim Biophys Acta. 2016,  2736(16)3000, 1-3. http://www.ncbi.nlm.nih.gov/pubmed/26801369
  12. Martin L, De Santis R, Koczera P, Simons N, Haase, Heinbockel LBrandenburg K, Marx G, Schuerholz T. The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis. PLoS One. 2015 Nov 23;10(11):e0143583. doi: 10.1371/journal.pone.0143583. eCollection 2015. http://www.ncbi.nlm.nih.gov/pubmed/26600070
  13. Dupont A, Heinbockel L, Brandenburg K, Hornef MW. Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa. Gut Microbes. 2014;5(6):761-765 (2014).
  14. Dupont A, Kaconis Y, Yang I, Albers T, Woltemate S, Heinbockel L, Andersson M, Suerbaum S, Brandenburg K, Hornef MW. Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide. Gut 64(2):222-232 (2015).
  15. Zuzuarregui A, Souto D, Pérez-Lorenzo E, Arizti F, Martínez de Tejada G, Moriyón I, Brandenburg K, Arana S, Mujika M. Novel integrated and portable endotoxin detection system based on an electrochemical biosensor. Analyst 140, 654-660 (2015).
  16. Sandetskaya N, Engelmann B, Brandenburg K, Kuhlmeier D. Application of immobilized synthetic anti-lipopolysaccharide peptides for the isolation and detection of bacteria. Eur J Clin Microbiol Infect Dis DOI 10.1007/s10096-015-2399-51 (2015)
  17. Ito H, Kuss N, Rapp BE, Ichikawa M, Gutsmann T, Brandenburg K, Poeschl JM, Tanaka M. Quantification of the Influence of Endotoxins on the Mechanics of Adult and Neonatal Red Blood Cells. J Phys Chem B. (2015) May 29. [Epub ahead of print]
  18. Brandenburg K, Schürholz T, Lack of new antiinfective agents: Passing into the pre-antibiotic age? World J. Biol. Chem. 2015 6(3):71-77.
    http://www.wjgnet.com/1949-8454/full/v6/i3/71.htm
  19. Martin L,, Schmitz S, De Santis R, Doemming S, Haase H, Hoeger J, Heinbockel L, Brandenburg K, Marx G, Schuerholz T. Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum. PLOS one 10 (2015)
  20. Heinbockel L, Marwitz S, Barcena Varela S, Ferrer-Espada R, Reiling N, Goldmann T, Gutsmann T, Mie W, Schürholz T, Drömann D, Brandenburg K, Martinez de Tejada G. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. PLOS one, July 21, 2015, DOI: 10.1371.
  21. Martinez de Tejada G, Heinbockel L, Ferrer-Espada R, Heine H, Alexander C, Bárcena-Varela S, Goldmann T, Correa W, Wiesmüller K-H, Gisch N, Sánchez-Gómez S, Fukuoka S, Schürholz T, Gutsmann T, Brandenburg K. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides. Sci Rep. 22 Sept.2015.
    www.nature.com/articles/srep14292
  22. Garidel P, Kaconis Y, Heinbockel L,Wulf M, Gerber S, Munk A, Vill V, Brandenburg K. Self-Organisation, Thermotropic and Lyotropic Properties of Glycolipids Related to their Biological Implications. The Open Biochemistry Journal, 2015, 9, 49-72.
    http://benthamopen.com/FULLTEXT/TOBIOCJ-9-49
  23. Heinbockel L, Martinez de Tejada G, Sánchez-Gómez S, Kaconis Y, Krause E, Brune W, Schmeiser S, Moennig V, Schürholz T, Dömming S, Hornef M, Dupont A, Hauber J, Garidel P, Schittl B, Lucifora J, Gutsmann T, Krepstakies M, Protzer U, Brandenburg K (2014). Anti-infective Polypeptides for Combating Bacterial and Viral Infections. Frontiers in Clinical Drug Research-Anti-Infectives. Vol.1, in press.
  24. Correa W, Manrique-Moreno M, Patiño E, Peláez-Jaramillo C, Kaconis Y, Gutsmann T, Garidel P, Heinbockel L, Brandenburg K. Galleria mellonella native and analogue peptides Gm1 and ΔGm1.I) Biophysical characterization of the interaction mechanisms with bacterial model membranes. Biochim. Biophys. Acta 1838, 2728-2736 (2014).
    http://www.ncbi.nlm.nih.gov/pubmed/25017800
  25. Correa W, Manrique-Moreno M, Behrends J, Patiño E, Marella C, Peláez-Jaramillo C, Garidel P, Gutsmann T, Brandenburg K, Heinbockel L. Galleria mellonella native and analogue peptides Gm1 and ΔGm1. II) Anti-bacterial and anti-endotoxic effects. Biochim. Biophys. Acta 1838, 2739-2744 (2014)
    http://www.ncbi.nlm.nih.gov/pubmed/25016054
  26. Heinbockel L, Palacios-Chaves L, Alexander C, Rietschel E, Behrends J, Correa W, Fukuoka S, Gutsmann T, Ulmer AJ, Brandenburg K. Mechanism of Hbγ-35-induced an increase in the activation of the human immune system by endotoxins. Innate Immunity Jul 16, (2014)
    http://www.ncbi.nlm.nih.gov/pubmed/25034969
  27. Gries A, Prassl R, Fukuoka S, Rössle M, Kaconis Y, Heinbockel L, Gutsmann T, Brandenburg K. Biophysical analysis of the interaction of the serum protein human β2GPI with bacterial lipopolysaccharide. FEBS Open Bio. 2014 May 2;4:432-40. doi: 10.1016/j.fob.(2014).
    http://www.ncbi.nlm.nih.gov/pubmed/24918058
  28. Hoffmann J, Schneider C, Heinbockel L, Brandenburg K, Reimer R, Gabriel G, A new class of synthetic anti-lipopolysaccharide peptides inhibits Influenza A virus replication by blocking cellular attachment. Antiviral Res. 2014 (in press).
    http://www.sciencedirect.com/science/article/pii/S0166354214000278
  29. Schurholz T, Heinbockel L, Martinez de Tejada G, . Hornef M, Marx G, and Brandenburg K. Neue Sepsistherapie am Horizont: Antiinflammatorische Peptide.
    DIVI 4: 0144–0152 (2013).
  30. Keese SP, Brandenburg K, Roessle M, Schromm AB. Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages. Innate Immun 2013, Pub ahead of print.
    http://www.ncbi.nlm.nih.gov/pubmed/24122298
  31. Sil D, Heinbockel L, Kaconis Y, Rössle M, Garidel P, Gutsmann T, David SA, Brandenburg K.. Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines. Open Biochem. J. 7, 83-93 (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/24133550
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  32. Abuillan W, Schneck E, Körner A, Brandenburg K, Gutsmann T, Gill T,
    Vorobiev A, Konovalov O, Tanaka M. Physical interactions of fish protamine and antisepsis peptide drugs with bacterial membranes revealed by combination of specular x-ray reflectivity and grazing-incidence x-ray fluorescence. Phys Rev E Stat Nonlin Soft Matter Phys. 88(1-1):012705. Epub (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/23944490
  33. Schuerholz T, Doemming S, Hornef M, Martin L, Simon T.-P.,Heinbockel L, Brandenburg K, and Marx G: The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study. Critical Care, 17:R3 (2013)
    http://www.ncbi.nlm.nih.gov/pubmed/23302299
  34. Richter W, Heinbockel L, Kaconis Y, Steiniger F, Brade L, and Brandenburg K. Cellular distribution of lipid A and LPS R595 after in vitro application to isolated human monocytes by freeze-fracture replica immunogold-labelling. nnate Immun 19 (6) 585 – 592 (2013)
    http://www.ncbi.nlm.nih.gov/pubmed/23405031
  35. Heinbockel L, Sánchez-Gómez S, Martinez de Tejada G, Dömming S, Brandenburg J, Kaconis Y, Hornef M, Dupont A, Marwitz S, Goldmann T, Ernst M, Gutsmann T, Schürholz T, and Brandenburg K. Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors. Antim.Agents Chemother. 57(3):1480-1487 (2013).
    http://www.ncbi.nlm.nih.gov/pubmed/23318793
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  36. Conde-Álvarez R, Arce-Gorvel V, Iriarte M, Manček-Keber M, Barquero-Calvo E, Palacios-Chaves L, Chacón-Díaz C, Chaves-Olarte E, Martirosyan A, von Bargen K, Grilló MJ, Jerala R, Brandenburg K, Llobet E, Bengoechea JA, Moreno E, Moriyón I, Gorvel JP. The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition. PLoS Pathog. 8(5):e1002675 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22589715
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  37. Schuerholz T, Dömming S, Hornef M, Dupont A, Kowalski I, Kaconis Y, Andrä J, Garidel P, Gutsmann T, David S, Sánchez-Gómez S, Martinez de Tejada G, and Brandenburg K, Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects, Curr Drug Targets 13(9):1131-1137 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22664073
  38. Martinez de Tejada G, Sánchez-Gómez S, Kowalski I, Kaconis Y, Andrä J, Schürholz T, Hornef M, Dupont A, Garidel P, Gutsmann T, David Sunil A, and Brandenburg K, Bacterial cell wall compounds as promising targets of antimicrobial agents, I. Antimicrobial peptides and lipopolyamines, Curr Drug Targets 13(9):1121-1130 (2012)
    http://www.ncbi.nlm.nih.gov/pubmed/22664072
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  39. Schuerholz T, Brandenburg K, and Marx G, Antimicrobial peptides and their
    potential application in inflammation and sepsis, Crit. Care 16, 207 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22429567
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  40. Manček-Keber M, Benčina M, Japelj B, Panter G, Andrä J, Brandenburg K, Triantafilou M, Triantafilou K and Jerala R, MARCKS as a negative regulator of LPS signaling, J. Immunol. 188(8):3893-902 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22427633
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  41. Krepstakies M, Lucifora J, Nagel C.-H., Zeisel M, Holstermann B., Hohenberg H, Kowalski I, Gutsmann T, Baumert T. F., Brandenburg K, Hauber J and Protzer U. Targeting virus attachment and entry by a new class of synthetic cross-species peptide inhibitors, J. Infect. Dis. 205(11):1654-1664 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/22457281
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  42. Fukuoka S, Richter W, Howe J, Andrä J, Rössle M, Alexander C, Gutsmann T, and Brandenburg K. Biophysical investigations into the interactions of endotoxins with bile acids. Innate Immunity 18(2):307-217 (2012).
    http://www.ncbi.nlm.nih.gov/pubmed/21954318
  43. Rappolt M, Rössle M, Kaconis Y, Howe J, Andrä J, Gutsmann T, and Brandenburg K. X-ray scattering of bacterial cell wall compounds and their neutralization , NOVA Science Publishers, pp. 133-148 (2011).
  44. Suwalsky M, Manrique-Moreno M, Howe J, Brandenburg K and Villen F. Molecular Interactions of Mefenamic Acid with Lipid Bilayers and Red Blood Cells. J. Braz. Chem. Soc. 12, 2243-2249 (2011)
  45. Jeworrek C, Evers F, Howe J, Brandenburg K, Tolan M, Winter R.
    Effects of Specific versus Nonspecific Ionic Intections on the Structure and Lateral Organization of Lipopolysaccharides. Biophys. J. 100, 2169-2177 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21539784
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  46. Kaconis Y, Kowalski I, HoweJ, Brauser A, Richter W, Razquin-Olazarán I, Iñigo-Pestaña M, Garidel P, Rössle M, Martinez de Tejada G, Gutsmann T, and Brandenburg K. Biophysical mechanisms of endotoxin neutralization by and its specificity for cationic amphiphilic peptides. Biophys. J. 100, 2652-2661 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21641310
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  47. Brandenburg K, Andrä J, Garidel P, and Gutsmann T. Peptide-based treatment of sepsis. Appl. Microbiol. Biotechnol. 90, 799-808(2011).
    http://www.ncbi.nlm.nih.gov/pubmed/21369803
  48. Sánchez-Gómez S, Japelj B, Jerala R, Moriyón I, Alonso MF, Leiva J, Blondelle SE, Andrä J, Brandenburg K, Lohner K, Martinez de Tejada G. Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo. Antimicr. Agents Chemother. 55, 218-228 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/20956602
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  49. Brandenburg K, Andrä J, Gutsmann T, Howe J, and Garidel P. Isothermal titration calorimetric studies of the interaction of phosphor- and glycolipids with anti-infective agents, In: Thermal Analysis in Medical Application', Editor Denes Lörincy, Akademiai Kiado, Budapest (2011).
  50. Richter W, Vogel V, Howe J, Steiniger F, Brauser A, Koch MHJ, Roessle M,
    Gutsmann T, Garidel P, Mäntele W, Brandenburg K. Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin. Innate Immun 17, 427-438 (2011).
    http://www.ncbi.nlm.nih.gov/pubmed/20682588
  51. Oliveira R, Schneck E, Quinn B, Konovalov O, Brandenburg K, Gutsmann T,
    Gill T, Hanna C, Pink D, Tanaka M. Crucial roles of charged saccharide moieties in survival of gram negative bacteria against protamine revealed by combination of grazing incidence X-ray structural characterizations and Monte Carlo simulations. Phys. Rev 81(4) (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20481747
  52. Brandenburg K, Howe J, Sánchez-Gómez S, Garidel P, Roessle M, Andrä J, Zweytick D, Lohner K, Rappolt M, Blondelle S, Moriyon I and Martinez de Tejada G. Effective Antimicrobial and Anti-Endotoxin Activity of Cationic Peptides Based on Lactoferricin: A Biophysical and Microbiological Study. Anti-infect Agents Medicin Chem 9, 9-22 (2010).
  53. T. Gutsmann, I. Razquin-Olazarán, I. Kowalski, Yani Kaconis, J. Howe, R. Bartels, M. Hornef3; T. Schürholz, M. Rössle, S. Sanchez-Gómez, I. Moriyon, G. Martinez de Tejada, K. Brandenburg. New antiseptic peptides to protect from endotoxin-mediated shock, Antimicrob. Agents Chemother. 54, 3817-3824 (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20606063
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  54. Kowalski I, Kaconis Y, Andrä J, Razquin-Olazarán I, Gutsmann T, Martinez de Tejada G, and Brandenburg K, Physicochemical and biological characterization of anti-endotoxin peptides and their influence on lipidproperties; Protein Pept. Lett. 17, 1328-1333 (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20673224
  55. Suomalainen M, Lobo LA, Brandenburg K, Lindner B, Virkola R, Knirel YA, Anisimov AP, Holst O, and Korkonen TK,Temperature-induced changes in the lipopolysaccharide of Yersinia pestis affect plasminogen activation by the Pla surface protease. Infect. Immun. 78: 2644-2652 (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20368351
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  56. Brandenburg K, Garidel P, Fukuoka S, Howe J, Koch MHJ, Gutsmann T, and Andrä J, Molecular basis for endotoxin neutralization by amphiphatic peptides derived from the alpha-helical cationic core-region of NK-lysin. Biophys. Chem. 150, 80-87 (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20153101
  57. Brandenburg K, Schromm AB, and Gutsmann T. Endotoxins: Relationship between structure, function, and activity, In: Subcellular Biochemistry, Vol. 53: Endotoxins: Structure, function, and recognition, (X. Wang and P.J. Quinn, Eds.) Springer-Verlag, pp. 65-79 (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20593262
  58. Schneck E, Schubert T, Konovalov OV, Quinn BE, Gutsmann T, Brandenburg K, Oliveira RG, Pink DA, and Tanaka M. Quantitative determination of ion distributions in bacterial lipopolysaccharide membranes by grazing-incidence X-ray fluorescence. Proc Natl Acad Sci U S A.107(20):9147-9151 (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/20442333
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  59. Schromm AB, Reiling N, Howe J, Wiesmüller KH, Roessle M, and Brandenburg, K. Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis. Innate Immunity 16, 213-225 (2010).
    http://www.ncbi.nlm.nih.gov/pubmed/19710101
  60. Brandenburg K. and Seydel U. Conformation and supramolecular structure of lipid A, Adv. Exp. Med. Biol. 667, 25-38 (2009)
  61. Brandenburg K., Garidel P., and Gutsmann T. Physicochemical properties of microbial glycopolymers, In: Microbial Glycobiology, (A.P. Moran, O. Holst, P.J. Brennan, M. von Itzstein, Eds.), E-book, Elsevier, pp. 759-779 (2009).
  62. 34Schneck E, Oliveira RG, Rehfeldt F, Demé B, Brandenburg K, Seydel, U, and Tanaka M. Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 80(4 Pt 1).
    http://www.ncbi.nlm.nih.gov/pubmed/19905364
  63. Garidel P. and Brandenburg K., Current Understanding of Polymyxin B Applications in Bacteraemia/Sepsis Therapy Prevention: Clinical, Pharmaceutical, Structural and Mechanistic Aspects, Antiinfect. Agents Medic. Chem. 8, 367-385 (2009)
  64. Kerth, A., Garidel P.,Howe J., Alexander C., Mach J.-P., Waelli T., Blume A, Rietschel E.Th., and Brandenburg K.. An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins. Medic. Chem. 6, 535-542 (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/19925448
  65. Brandenburg K., Howe J, Gutsmann T, and Garidel P. The expression of endotoxic activity in the Limulus test as compared to cytokine production in immune cells. Curr. Med. Chem. 16, 2653-2660 (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/19601802
  66. Gutsmann T, Howe J, Zähringer U, Garidel P, Schromm AB, Koch MHJ, Fujimoto, Y.,Moriyon I, Martínez-de-Tejada G, and Brandenburg K. Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells. Innate Immun. 16: 39-47 (2009).
    http://www.ncbi.nlm.nih.gov/pubmed/19567486